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2024/03/11
Doctor Detail

Dr Daniel Huang

Photo of Dr Daniel Huang

Designations:

  • Consultant, Division of Gastroenterology and Hepatology, Department of Medicine, National University Hospital
  • Consultant, Adult Liver Transplantation Programme, National University Centre for Organ Transplantation, National University Hospital
  • Assistant Professor, Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore

Qualifications:

MBBS (S'pore), MMED (Int Med)(S'pore), MRCP (UK)

Specialties/Sub-specialties:

Gastroenterology

Clinical Disciplines/Programmes:

Adult Liver Transplantation Programme, Gastroenterology & Hepatology, Medicine, Organ Transplantation

Biosketch

Dr. Daniel Q. Huang graduated from the Yong Loo Lin School of Medicine, National University of Singapore. He leads hepatocellular carcinoma research in the Division of Gastroenterology and is also proficient in diagnostic and therapeutic endoscopy.

Dr. Huang’s research interest is in the early detection and prevention of hepatocellular carcinoma in non-alcoholic fatty liver disease and viral hepatitis. Dr. Huang is working on non-invasive strategies to risk stratify and assess treatment response in NASH and hepatocellular carcinoma by leveraging advanced imaging-, genomic-, and RNA-based approaches. Dr. Huang also has an interest in hepatitis B and has led several studies on the indeterminate phase, contributing to an expansion of the treatment indications for chronic hepatitis B in the latest World Health Organization guidelines (2024) to include the indeterminate phase. Dr. Huang has co-authored clinical practice guidelines on behalf of the American Gastroenterology Association and is contributing to several guidance statements of the Asia Pacific Association for the Study of the Liver (APASL).

Dr. Huang has published more than 200 peer-reviewed articles, with first or corresponding authorship in journals such as Cell Metabolism, Gastroenterology, Hepatology, Nature Reviews Disease Primers, Gut, the Lancet Gastroenterology and Hepatology, and the Lancet Oncology. He has received awards for his research from the American Association for the Study of Liver Diseases (AASLD) and the European Association for the Study of the Liver (EASL). Dr. Huang is a frequent invited speaker at international scientific meetings, such as the AASLD, the American Association for Cancer Research (AACR), the APASL, and in multiple regional meetings in Asia. His research is funded by several grants, including the transition award from the National Medical Research Council. He currently serves as the Hepatology chair of the Emerging Leaders Committee (Asia Pacific Gastroenterology Association) and as an Associate Editor of Alimentary Pharmacology and Therapeutics.

Area of Interest:

  • Hepatocellular carcinoma
  • Non-alcoholic fatty liver disease
  • Cirrhosis
  • Non-invasive tests for fibrosis and steatosis
  • Chronic hepatitis B

Journals & Publications

  1. Tan EY et al.. and Huang DQ. Liver cancer in 2021: Global burden of disease study. J Hepatol. 2024 Oct 30:S0168-8278(24)02652-7.
  2. Huang, D. Q., Wilson, A.W, Behling, C. et al. Fibrosis Progression Rate in Biopsy-proven Nonalcoholic Fatty Liver Disease among People with Diabetes versus People without Diabetes: A Multicenter Study. Gastroenterology (2023).
  3. Loomba R, …. and Huang DQ. MASH Resolution Index: development and validation of a non-invasive score to detect histological resolution of MASH. Gut. 2024 Jul 11;73(8):1343-1349. doi: 10.1136/gutjnl-2023-331401.
  4. Huang, D. Q., Fowler, K. J., Liau, J., et al. (2022). Comparative efficacy of an optimal exam between ultrasound versus abbreviated MRI for HCC screening in NAFLD cirrhosis: A prospective study. ALIMENTARY PHARMACOLOGY & THERAPEUTICS, 55(7), 820-827. doi:10.1111/apt.16844
  5. Huang DQ, Wong VWS, Rinella ME, et al. Metabolic dysfunction-associated steatotic liver disease in adults. Nat Rev Dis Primers. 2025 Mar 6;11(1):14.
  6. Huang D.Q., Tran A, Yeh ML, et al. Antiviral therapy substantially reduces hepatocellular carcinoma risk in chronic Hepatitis B patients in the indeterminate phase. Hepatology. 2023 May 16. doi: 10.1097/HEP.0000000000000459.
  7. Huang D.Q., Nourredin N, Ajmera V, et al. Type 2 Diabetes Mellitus, Hepatic Decompensation and Hepatocellular Carcinoma in Nonalcoholic Fatty Liver Disease: Individual Participant Data Meta-analysis. The Lancet Gastroenterology and Hepatology 2023.
  8. Huang D.Q., Sharpton SR, Amangurbanova M, et al. Clinical Utility of Combined MRI-PDFF and ALT Response in Predicting Histologic Response in Nonalcoholic Fatty Liver Disease. Clin Gastroenterol Hepatol. 2022 Sep 6:S1542-3565(22)00832-1. doi: 10.1016/j.cgh.2022.08.036.
  9. Zheng M, Huang D.Q., Konkwo C, et al. Genomic analysis of lean individuals with NAFLD identifies monogenic disorders in a prospective cohort study. JHEP Rep. 2023 Feb 2;5(4):100692.
  10. Huang, D. Q., Muthiah, M. D., Zhou, L et al. (2021). Predicting HCC Response to Multikinase Inhibitors With In Vivo Cirrhotic Mouse Model for Personalized Therapy. Cellular and Molecular Gastroenterology and Hepatology, 11(5), 1313-1325. doi:10.1016/j.jcmgh.2020.12.009.

Professional Memberships

  • Gastroenterological Society of Singapore (GESS)
  • American Association for the Study of Liver Diseases
  • Fellow of the Royal College of Physicians (UK)

2025/04/14
1E Kent Ridge Road, NUHS Tower Block, Singapore 119228
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National University Health System
  • National University Hospital
  • Ng Teng Fong General Hospital
  • Alexandra Hospital
  • Jurong Community Hospital
  • National University Polyclinics
  • Jurong Medical Centre
  • National University Cancer Institute, Singapore
  • National University Heart Centre, Singapore
  • National University Centre for Oral Health, Singapore
  • NUHS Diagnostics
  • NUHS Pharmacy
  • Yong Loo Lin School of Medicine
  • Faculty of Dentistry
  • Saw Swee Hock School of Public Health
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