Patient Care

Major Depressive Disorder

2023/10/12
What is Major Depressive Disorder?

A depressive disorder is not the same as a passing blue mood. It is not a sign of personal weakness or a condition that can be willed or wished away. People with a depressive illness cannot merely "pull themselves together" and get better. Without treatment, symptoms can last for weeks, months, or years. Depression is a common but serious illness, and most people who experience it need treatment to get better.

Major depression is manifested by a combination of symptoms (see symptom list) that interfere with the ability to work, study, sleep, eat, and enjoy once pleasurable activities. Such a disabling episode of depression may occur only once but more commonly occurs several times in a lifetime. A depressive disorder is an illness that involves the body, mood, and thoughts. It interferes with daily life, normal functioning, and causes pain for both the person with the disorder and those who care about him or her.

What are the signs & symptoms of Major Depressive Disorder?

Not everyone who is depressed experiences every symptom. Some people experience a few symptoms, some many. Severity of symptoms varies with individuals and also varies over time.

  • Appetite and/or weight loss, or overeating and weight gain
  • Decreased energy, fatigue, being "slowed down"
  • Difficulty concentrating, remembering, or making decisions
  • Feelings of guilt, worthlessness, or helplessness
  • Feelings of hopelessness or pessimism
  • Insomnia, early morning awakening or oversleeping
  • Loss of interest or pleasure in hobbies and activities that were once enjoyed
  • Restlessness, irritability
  • Persistent physical symptoms that do not respond to treatment, such as headaches, digestive disorders and chronic pain
  • Persistent sad, anxious, or empty mood
  • Thoughts of death or suicide, suicide attempts
What are the treatment options for Major Depressive Disorder?

Depression, even the most severe cases, is a highly treatable disorder. As with many illnesses, the earlier that treatment can begin, the more effective it is and the greater the likelihood that recurrence can be prevented.

Appropriate treatment for depression starts with a physical examination by a physician. Certain medications, as well as some medical conditions such as viral infections or a thyroid disorder, can cause the same symptoms as depression, and the physician should rule out these possibilities through examination, interview and lab tests. If a physical cause for the depression is ruled out, a psychological evaluation that includes a mental status examination should be done either by the physician or by referral to a mental health professional.

He or she should discuss any family history of depression including their treatment, and get a complete history of symptoms, such as when they started, how long they have lasted, how severe they are, whether the patient had them before. And if so, whether the symptoms were treated and what treatment was given. The doctor should ask about alcohol and drug use, and if the patient has thoughts about death or suicide.

Once diagnosed, a person with depression can be treated with a number of methods. The most common treatments are medication and psychotherapy.

Find A Doctor

Click here to access our Find A Doctor directory for a list of doctors treating this condition across our NUHS institutions.

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  • Condition name 'Major Depressive Disorder' AND
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