Memory Ageing and Cognition Centre (MACC)

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Memory Ageing and Cognition Centre (MACC)

$6mil Centre Grant over 4 years (2010-2014), funded by National Medical Research Council
$3.2mil Centre Grant over 4 years (2013-2018), funded by National Medical Research Council

 

 


Aims and Research Theme

 

One area of dementia research important to Singapore and Asia is Vascular & Neurodegenerative Mechanisms in Dementia. Vascular disease is prominent among ethnic Asian dementia patients. Compared to Caucasian populations, a higher prevalence of VaD has been reported in Asian countries such as Japan and China. Moreover, studies have revealed a vascular basis contributing to the etiology and pathogenesis of AD. The identification of biomarkers for vascular and neurodegenerative mechanisms, and insights into the mechanisms of interaction may lead to potential therapeutic approaches.


This will not only give rise to novel scientific insights and advances but also be of immense potential benefit to Singaporeans and the biomedical industry since the increasing numbers of patients suffering from dementia exact a massive toll in health care costs, disability and lost productivity for both patients and caregivers.


NUHS can play a vital role in translational clinical dementia research because of strong interactions between clinical and basic science departments, which may lead to interventions that can prolong independent community function, delay institutionalisation and therefore lower healthcare expenditure.

 

C11-PIB PET in NUS First Scans in April 2016

 

The clinical and epidemiological studies will provide novel insights into the risk factors and biomarkers for dementia as well as patients for biomarker and interventional studies of cognitive decline and dementia.

 

These clinical cohorts will be recruited into Neuroimaging (MRI and retinal imaging) studies which may in turn help identify high risk groups for intervention as well as mechanisms to be targeted for further investigations, as may the Neurochemical studies on brain samples and Animal Models which will also provide opportunities to validate biomarkers.

 
 
 

Core Research Projects:

 

  1. Neurochemistry, Molecular Pathology and Biomarker Discovery
  2. Dementia Neuroimaging using Multi-Modal Magnetic Resonance and Retinal Imaging
  3. Improving the Diagnosis of Vascular Cognitive Impairment by Prospective Longitudinal Clinical Studies
  4. Epidemiology of Dementia in Singapore: Ethnicity and Risk Factors  

 

 

 

  Retinal imaging

  1. Prof. Geert-Jan BIESSELS   Professor of Neurology, Brain Center Rudolf Magnus Institute, University of Utrecht Medical Center, Netherlands
    Topics: 
    1. Cerebral microinfarcts: an update on detection, risk factors, and functional consequence
    2. Diagnostic criteria for vascular contributions to cognitive impairment and dementia: Babylonian confusion?
  2. A/Prof. Christopher CHEN   Director, Memory Aging and Cognition Centre, National University Health System, National University of Singapore
    Topic: 
    From Micro to Molecular : Advances in Neuroimaging for Cognitive Impairment and Dementia
  3. Dr. Carol CHEUNG   Assistant Professor, Department of Ophthalmology & Visual Sciences, The Chinese University of Hong Kong
    Topic: 
    Imaging Retina to Study Dementia: an Overview and its Potential
  4. A/Prof. Nagaendran KANDIAH   Director of Dementia Programme & Senior Consultant, Department of Neurology, National Neuroscience Institute
    Topic: 
    White Matter Hyperintensities: Etiology, Impact on Cognition and Management
  5. Dr. Elijah MAK   Research Associate, Department of Psychiatry, University of Cambridge
    Topic: 
    Amyloid imaging and structural brain changes in Lewy body dementia
  6. Dr. Kok Pin NG   Consultant, Department of Neurology, National Neuroscience Institute
    Topic: 
    Neuropsychiatric symptoms in pre-clinical and clinical dementia : new insights from neuroimaging studies
  7. Prof. John O’BRIEN   Professor, Department of Psychiatry, University of Cambridge
    Topics: 
    1. Tau imaging in dementia and other neurodegenerative disorders
    2. Can imaging changes be detected 20 years before dementia onset?
  8. Dr. Juan Helen ZHOU   Assistant Professor, Neuroscience and Behavioural Disorders Programme, Duke-NUS Medical School, Singapore
    Topic: 
    Network-based brain structural and functional changes from preclinical to clinical neurodegenerative disorders

  1. Yuek Ling CHAI   PhD student, Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore
    Topic: 
    Blood Biomarkers: The Brain Heart Connection - Cardiac markers in cognitive impairment and dementia
  2. Victor CHAN   Faculty of Medicine, The Chinese University of Hong Kong
    Topic: 
    Retinal Imaging: Associations between retinal changes and amyloid-beta burden
  3. Dr. Danny CHEUNG   Associate Consultant, Surgical Retina Department, Singapore National Eye Centre
    Topic: 
    Retinal Imaging: Associations of Retinal Signs with Cerebrovascular Disease and Neurodegeneration in the Brain - the Epidemiology of Dementia in Singapore (EDIS) Study
  4. Su Xian, Joanna CHONG   PhD Student, Neuroscience and Behavioural Disorders Programme, Duke-NUS Medical School, Singapore
    Topic: 
    Neuroimaging I: Influence of Alzheimer's disease and cerebrovascular disease on brain functional networks
  5. Dr. Jacqueline CHUA   Senior clinical research fellow, Ocular imaging, Singapore Eye Research Institute
    Topic: 
    Retinal Imaging: Recent Developments in Retinal Imaging for Dementia
  6. Dr. Chester Lee DRUM   Consultant, Department of Cardiology, National University Heart Centre, Singapore & Assistant Professor, Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore
    Topic: 
    Blood Biomarkers: General overview of the use of Mass Spectroscopy in clinical biomarker discovery
  7. Daniel FAKHRY-DARIAN   Medical Physicist, Clinical Imaging Research Centre, A*STAR-National University of Singapore
    Topic: 
    Neuroimaging II: Application of Machine Learning to C-11 PiB Classification
  8. Bibek GYANWALI   PhD student, Memory Aging and Cognition Centre, National University Health System, National University of Singapore
    Topic: 
    Neuroimaging III: Prevalence, risk factors, progression and incidence of cerebral small vessel disease markers in an Asian population
  9. Dr. Deron Raymond HERR   Assistant Professor, Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore
    Topic: 
    Blood Biomarkers: Alterations in sphingosine 1-phospate composition in the plasma of VaD patients
  10. Fang JI   PhD Student, Neuroscience and Behavioural Disorders Programme, Duke-NUS Medical School, Singapore
    Topic: 
    Neuroimaging I: White matter extracellular water increases and tissue damage in the prodromal and clinical Alzheimer’s disease
  11. Dr. Siwei LIU   Research Fellow, Neuroscience and Behavioural Disorders Programme, Duke-NUS Medical School, Singapore
    Topic: 
    Neuroimaging I: The association between retinal neuronal layer and brain structure is disrupted in patients with cognitive impairment and Alzheimer’s disease
  12. Xiao LUO   Joint PhD Student, Neuroscience and Behavioural Disorders Programme, Duke-NUS Medical School, Singapore
    Topic: 
    Neuroimaging I: Predictive brain structure, amyloid and behavioural features for clinical progression in subjective memory concern
  13. Dr. Kwun Kei NG   Senior Research Fellow, Neuroscience and Behavioural Disorders Programme, Duke-NUS Medical School, Singapore
    Topic: 
    Neuroimaging I: Longitudinal changes in brain functional connectivity in healthy older adults and the influence of APOE e4 genotype
  14. Dr. Yi-ting ONG   Duke-NUS Medical School, Singapore
    Topic: 
    Retinal Imaging: Retinal microvascular changes in dementia patients with infarcts
  15. Dr. Anthonin REILHAC   Principal Investigator, Clinical Imaging Research Centre, A*STAR-National University of Singapore
    Topic: 
    Neuroimaging II: Good quality PET data in dementia
  16. Dr. Francis SARIDIN   Research Fellow, Department of Pharmacology, National University of Singapore
    Topic: 
    Neuroimaging III: The interaction between APOE genotype, amyloid burden, cerebrovascular disease and cognitive impairment
  17. Dr. Huilin SHAO   Assistant Professor, Department of Biomedical Engineering, Faculty of Engineering, National University of Singapore
    Topic: 
    Blood Biomarkers: Molecular analysis of circulating exosomes from dementia patients using biosensor platforms
  18. Dr. Mary STEPHENSON   Senior Research Fellow, Clinical Imaging Research Centre, A*STAR-National University of Singapore
    Topic: 
    Neuroimaging II: Investigating the pathway to Alzheimer's disease: Amyloid, Atrophy and Neurotransmission.
  19. Dr. Ashley Ann WEEKES   Head of Radiopharmaceutical Production, Clinical Imaging Research Centre, A*STAR-National University of Singapore
    Topic: 
    Neuroimaging II: Current trends in radiopharmaceuticals for Alzheimer's disease
  20. Dr. Chathuri J YATAWARA   Research Fellow, National Neuroscience Institute, Singapore
    Topic: 
    Neuroimaging III: Understanding Neural Mechanisms for Getting lost behaviour in Alzheimer’s disease
  21. Dr. Liwen ZHANG   Research Fellow, Neuroscience and Behavioural Disorders Programme, Duke-NUS Medical School, Singapore & Memory Aging and Cognition Centre, National University Health System, National University of Singapore
    Topic: 
    Neuroimaging III: Cortical cerebral microinfarcts influence structural network topology in clinical and prodromal dementia