Epidemiology & Public Health
Tan JT, Nurbaya S, Gardner D, Ye S, Tai ES, Ng DP.
Genetic variation in KCNQ1 associates with fasting glucose and beta-cell function: a study of 3,734 subjects comprising three ethnicities living in Singapore. Diabetes. 2009 Jun;58(6):1445-9.
Super Tier Publication
Yannay-Cohen N, Carmi-Levy I, Kay G, Yang CM, Han JM, Kemeny DM, Kim S, Nechushtan H, Razin E. LysRS serves as a key signaling molecule in the immune response by regulating gene expression. Mol Cell. 2009 Jun ;34(5):603-11
Lysyl-tRNA synthetase (LysRS) was found to produce diadenosine tetraphosphate (Ap(4)A) in vitro more than two decades ago. Here, we used LysRS silencing in mast cells in combination with transfected normal and mutated LysRS to demonstrate in vivo the critical role played by LysRS in the production of Ap(4)A in response to immunological challenge. Upon such challenge, LysRS was phosphorylated on serine 207 in a MAPK-dependent manner, released from the multisynthetase complex, and translocated into the nucleus. We previously demonstrated that LysRS forms a complex with MITF and its repressor Hint-1, which is released from the complex by its binding to Ap(4)A, enabling MITF to transcribe its target genes. Here, silencing LysRS led to reduced Ap(4)A production in immunologically activated cells, which resulted in a lower level of MITF inducible genes. Our data demonstrate that specific LysRS serine 207 phosphorylation regulates Ap(4)A production in immunologically stimulated mast cells, thus implying that LysRS is a key mediator in gene regulation.
Anwar A, Leong KM, Ng ML, Chu JJ, Garcia-Blanco MA
The polypyrimidine tract-binding protein is required for efficient dengue virus propagation and associates with the viral replication machinery. J Biol Chem. 2009 Jun 19;284(25):17021-9
Lamoureux EL, Saw SM, Thumboo J, Wee HL, Aung T, Mitchell P, Wong TY.
The impact of corrected and uncorrected refractive error on visual functioning: the Singapore Malay Eye Study. Invest Ophthalmol Vis Sci. 2009 Jun;50(6):2614-20.
Nang EE, Khoo CM, Tai ES, Lim SC, Tavintharan S, Wong TY, Heng D, Lee J.
Is there a clear threshold for fasting plasma glucose that differentiates between those with and without neuropathy and chronic kidney disease?: the Singapore Prospective Study Program. Am J Epidemiol. 2009 Jun 15;169(12):1454-62.
Amerasinghe N, Foster PJ, Wong TY, Htoon HM, He M, Shen SY, Aung HT, Saw SM, Aung T.
Variation of angle parameters in asians: an anterior segment optical coherence tomography study in a population of singapore malays. Invest Ophthalmol Vis Sci. 2009 Jun;50(6):2626-31.
Kumarasuriyar A, Lee I, Nurcombe V, Cool SM.
De-sulfation of MG-63 cell glycosaminoglycans delays in vitro osteogenesis, up-regulates cholesterol synthesis and disrupts cell cycle and the actin cytoskeleton. J Cell Physiol. 2009 Jun;219(3):572-83.
Sethi G, Tergaonkar V.
Potential pharmacological control of the NF-kappaB pathway. Trends Pharmacol Sci. 2009 Jun;30(6):313-21.
Chee MW, Chen KH, Zheng H, Chan KP, Isaac V, Sim SK, Chuah LY, Schuchinsky M, Fischl B, Ng TP.
Cognitive function and brain structure correlations in healthy elderly East Asians. Neuroimage. 2009 May 15;46(1):257-69.
Broekman BF, Chan YH, Chong YS, Quek SC, Fung D, Low YL, Ooi YP, Gluckman PD, Meaney MJ, Wong TY, Saw SM.
The influence of birth size on intelligence in healthy children. Pediatrics. 2009 Jun;123(6):e1011-6.