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NMRC Clinicial Trial Grant

 

 NMRC Clinical Trial Grant (CTG) Launch

 

The CTG aims to support clinicians in carrying out clinical trial studies for the development of novel therapies for healthcare needs. There are three schemes under the CTG programme, namely the (i) Co-Development Scheme which supports clinicians who wish to collaborate with the industry, and the Investigator-Initiated Trials - (ii) Early Phase and (iii) Late Phase Schemes which support clinicians who wish to conduct clinical trial studies on therapies of their own interest. These will help to develop the next generation of clinical investigators, promote translational and clinical research studies, and move promising ideas from bench to bedside.

 

This grant programme comprises of three schemes, namely i) Co-Development Scheme (Co-D), ii) Investigator-Initiated Trials - Early Phase Scheme (IIT- E) and iii) Investigator-Initiated Trials - Late Phase Scheme (IIT-L).

 

i. For the CTG Co-Development (Co-D) Scheme: it is open throughout the year (there will not be a formal grant call). Applicants can submit their proposals through NUHS Research Office to NMRC at any time of the year.

 

Please click here for more details on NMRC CTG Co-D Scheme.

 

ii. For the IIT - Early and Late Phase Schemes: proposals will be submitted in response to a formal NMRC CTG grant call. 2 grant calls are scheduled in this year.

 

 Please refer to the NMRC website for more details.

 

Funding Information 

 


a) The maximum funding quantum for each project funded under IIT-E Scheme:


 

   Capped Amount

Maximum Duration

S $5 million (incl. 20% IRC)

         3 years

 

This scheme will support the conduct of investigator-initiated Phase I and II clinical trials.

 

Criteria:

(i) The scheme should preferably support the development of locally produced assets, ideas and compounds.

(ii) Partnership with industry is optional. However, the IP must reside in Singapore.

 

b) The maximum funding quantum for each project funded under IIT-L Scheme:

 

   Capped Amount

Maximum Duration

S $2 million (incl. 20% IRC)

         3 years

 

This scheme will provide partial support for late Phase III and IV clinical trials that are investigator-initiated.

 

Criteria:

(i) Partnership with industry is optional.

 

Eligibility Criteria

 

For Lead Principal Investigator

Each grant application must be submitted by a Clinical Principal Investigator who has to fulfil the following eligibility criteria listed below. Only one Lead Principal Investigator (PI)* is allowed per application. The lead PI is expected to be actively involved in the overall management of the project and will be accountable for the project and its deliverables.

a) Must fulfil HSA's requirements for PIs who are conducting clinical trials. Please refer to HSA website for detailed guidelines on conducting clinical trials:


http://www.hsa.gov.sg/publish/hsaportal/en/health_products_regulation/clinical_trials.html

http://www.hsa.gov.sg/publish/hsaportal/en/health_products_regulation/clinical_trials/faqs.html

 

b) Must be clinically qualified (i.e. with MD/MBBS/BDS) with clinical specialty certification, and post-graduate clinical training and experience. For proposals involving patients, the clinical PI should be SMC registered; or the PI should be able to demonstrate ability to access patients through SMC registered collaborators.

 

c) Must hold a primary appointment and be full time employed and salaried in a local public hospital/public health institution/national specialty centre/public university/academic medical centre.

 

d) Must be an independent PI with a demonstrated track record of research as evidenced by the award of nationally competitive funding (international funding to be considered on a case-by-case basis), or substantial publication record.

 

e) Have a laboratory or clinical research program that carries out research in Singapore.

 

f) Full time residency in Singapore.

 

g) No outstanding reports from previous BMRC, NMRC grants and other national grants.

 

 

For co-Investigators and Collaborators

 

  • Co-Is need to hold at least an adjunct position in a local public institution.

 

  • Researchers from overseas institutions or private companies can only participate as collaborators. The terms of collaboration with overseas research institutions and private companies must conform to NMRC's existing policies. 

 

Application Procedure

 

 1. One softcopy submission, without signatures, is required. Softcopy Application Form must be saved as a single Microsoft Word document and rename the document in the following format and send to grant_ro@nuhs.edu.sg for submission:


For IIT-E Scheme - "CTG_IITE_Feb2013_Lead PI Name_Institution Name"
For IIT-L Scheme - "CTG_IITL_Feb2013_Lead PI Name_Institution Name"

 

2. One hardcopy submission, with both original PI's signature and Host Institutions' endorsements, is required.  Co-Is/collaborators' signatures can be photocopies or faxed copies

 

3. As either the hardcopy or softcopy application may be sent for peer review, the PIs are to ensure that both versions are identical.

 

3.  Please submit the following to NUHS Research Office (Attn to : Dorothy Er)

 

NUS PIs  NUH PIs

 

Note: Under the "Checklist of Other Resources.." item (1) in NUS GEF, kindly indicate the space that will be allocated to your staff, if funded. If you will be using IMU services, please indicate and specify under item 2) as well.

  • NUHS RO Budget Template (For Clinical Trials) (1 softcopy and 1 hardcopy)

 

Hardcopy of NMRC CTG application form (complete with Lead PI/Co-Is/Collaborators' signatures, CVs, abstracts of all grants listed in section 19, KPIs of currently held NMRC grants and docs detailing areas of overlap where applicable)- Note : PI original signature is required and co-Is/collaborators' signatures can be photocopies or faxed copies.

 

• Forward the Softcopy of NMRC CTG application form to Grant_RO@nuhs.edu.sg (Attn to: Dorothy Er / Sharon Wee )

 

Note:
Softcopy Application Form (without signatures) must be saved as a single Microsoft Word document. The document will include all annexes, pictures, tables, charts and attachments, if any. Please adhere to the specified number of pages where applicable. The softcopy should not contain blank or irrelevant pages.

 

 

 

Note: Under the "Checklist of Other Resources.." item (1) in NUH GEF, kindly indicate the space that will be allocated to your staff, if funded. If you will be using IMU services, please indicate and specify under item 2) as well. 

  • NUHS RO Budget Template (For Clinical Trials) (1 softcopy and 1 hardcopy)

 

Hardcopy of NMRC CTG application form (complete with Lead PI/Co-Is/Collaborators' signatures, CVs, abstracts of all grants listed in section 19, KPIs of currently held NMRC grants and docs detailing areas of overlap where applicable) - Note : PI original signature is required and co-Is/collaborators' signatures can be photocopies or faxed copies.

 

• Forward the Softcopy of NMRC CTG application form to Grant_RO@nuhs.edu.sg (Attn to: Dorothy Er / Sharon Wee)

 


Note:
Softcopy Application Form (without signatures) must be saved as a single Microsoft Word document. The document will include all annexes, pictures, tables, charts and attachments, if any. Please adhere to the specified number of pages where applicable. The softcopy should not contain blank or irrelevant pages.

 

 

PIs are responsible to ensure all applications for IIT - Early and Late Phase Schemes to be submitted to NUHS Research Office by 15 April 2013, 12 noon for endorsements and checks. Any late or incomplete submissions or submissions from individual applicants without endorsement from the Host Institution or walk-in submissions (by the PIs or any representatives) will NOT be accepted by NMRC.

 

 

Other Points to Note :

  1. Please do not staple the hardcopy forms. Kindly use paperclips/ binder clips to bind them together instead.
  2. Please kindly state "NUHS" as your host institution in the application form.
  3. Use Arial font size 10 for all attachments/text.
  4. Indicate "NA" where a particular section is not applicable. Please also indicate lead PI's name and the amount of grant applied for (inclusive of 20% IRC costs) in the header provided on every page of the application form and including additional pages. Please refer to Annex 1 of the NMRC CTG application form for more details on fundable and non-fundable items.
  5. Please be reminded that each lead PI is to prepare his/her proposal based on the guidelines and instructions stipulated by the grantor. Incomplete applications or those that do not comply with grantor's specific requirements will not be considered for funding.

 

 

Kindly note

  1. If the proposed study requires biospecimen or tissue banking, please contact Dr Eng Chon Boon (chon_boon_eng@nuhs.edu.sg ) from the NUHS Tissue Repository. The tissue repository will assist with the biobanking budget. Kindly visit http://medicine.nus.edu.sg/tissue/Cost%20Recovery%20Schedule.pdf
  2. PIs may refer to the range of services provided by the Investigational Medicine Unit from their website (http://www.imu.com.sg ).
  3. PIs should refer to NUHS's internal processes for conducting clinical trials ( http://www.nuhs.edu.sg/research/clinical-research/clinical-trials/application-for-clinical-trials.html )

 

Attachments

 

 

Please download the following for detailed information pertaining to NMRC CTG.


01 : Clinical Trial Grant (CTG) 2013 Application Guide


02 : Clinical Trial Grant (CTG) 2013 Application Form

 

03 : NUH Grant Endorsement Form / NUS Grant Endorsement Form

 

04 : NUHS RO Budget Template (For Clinical Trials)

 

Contact Us

 

Please contact the following staff if you have any enquiries.

Ms Sharon Wee DID : 6772 3709  Email : sharon_wee@nuhs.edu.sg
Ms Dorothy Er DID : 6772 7576  Email : dorothy_er@nuhs.edu.sg