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Bill & Melinda Gates Foundation Letters of Inquiry (LOI): TB Vaccine Accelerator



The prevention of tuberculosis (TB) through the development and deployment of an effective vaccine is a priority of the Bill & Melinda Gates Foundation (BMGF). To strengthen the pipeline of vaccine candidates and enable a more rational and accelerated vaccine development process, BMGF, in collaboration with its Product Development Partner Aeras, recently launched the TB Vaccine Accelerator Program.


With the assistance and support of the TB research and development community, a set of obstacles to TB vaccine development—and integrated goals that, collectively, could help to directly understand, overcome or work around these obstacles—have been selected. Through a research program focused on achieving this defined set of interdependent goals, the TB Vaccine Accelerator aims to address significant challenges in this field.


Please refer to the website or FAQ for more information.




Funding Information

The maximum funding quantum for each project:

Capped Amount

Maximum Duration

Unspecified – aggregate total is USD20mil

3 years

                   The foundation allows a maximum of 15% IRC


Application Criteria

  1. Applicant must at least be affiliated with an University or from a for-profit organization.


    The goals of this LOI:

    Ø  To develop novel approaches to vaccination against Mycobacterium tuberculosis (MTB), with a particular focus on approaches that aim to induce protection against infection with MTB

    Ø  To develop models of natural MTB transmission and/or methods for defining the relevant molecular and biological characteristics of naturally transmitted mycobacteria and the interactions of such with vertebrate hosts.



Application Procedure

A. Online application – Deadline: Monday, 26 November 2012 (11.59pm PST)

a.    Interested PIs are required to create an account online in order to submit their proposal if they do not already have an account.

b.    PIs are to submit the application through the Online Application Tool by the deadline stipulated (Web Link for log-in provided above).

c.    Please use the LOI Application Form provided

d.    PIs are to read the LOI Instructions and TB Vaccine Accelerator Rules and Guidelines carefully before application

e.    The Letter of Inquiry submitted should be only up to four-pages. Please use 10-point font and 1-inch margins. Page size should be set to U.S. letter standard 8.5 x 11.0 inches.


B. Please forward the following documents to NUHS Research Office – Deadline: Monday, 26 November 2012




·         Original-signed NUS Grant Endorsement Form 

·         Forward the Softcopy of LOI to Grant_RO@nuhs.edu.sg  

·      Original-signed NUH Endorsement Form  

·      Forward the Softcopy of LOI to Grant_RO@nuhs.edu.sg  



Kindly Note:

If the proposed study would requires biospecimen or tissue banking, please contact Dr Eng Chon Boon (chon_boon_eng@nuhs.edu.sg) from the NUHS Tissue Repository. The tissue repository will assist in biobanking budgetary. Kindly visit: http://medicine.nus.edu.sg/tissue/Cost%20Recovery%20Schedule.pdf



Contact Us

Please contact the following staff if you have any enquiries:


Ms Clarin Ng

Tel : 6772 3723

Email : mednsy@nus.edu.sg